Current Projects

Completed Projects

Project 1

Genome-Wide Multi-Trait and Multimodal Single-Cell Analyses of Smoking Behaviours and Schizophrenia Reveal Novel Risk Loci and Regulatory Mechanisms
Project Lead & First Author | 2024–2025

Authors: Suzan Farhang-Sardroodi, Jennie G. Pouget, Saori Sakaue, Kathryn Weinand, Soumya Raychaudhuri, Jo Knight, Rachel F. Tyndale, and Meghan J. Chenoweth.

Led the computational design and integrative implementation of a multimodal analytical framework combining MTAG, Bayesian fine-mapping, eQTL colocalization, and single-cell regulatory mapping to identify genetic mechanisms linking smoking behaviours and schizophrenia. Prioritized candidate genes including SYNDIG1L, TMEM163, CKB, and SLC8A2, revealing regulatory pathways and potential translational psychiatric targets.

Virtual Seminar, CAMH Addiction Research Rounds, Toronto, Canada, April 17, 2025 (12-1 pm online on Webex), (received a formal letter of thanks for this presentation)

Recorded Presentation: Available through CAMH Webex

Project 2

Population Pharmacokinetic Analysis of Nicotine in African Green Monkeys: Disentangling Sex, Age, and Body Weight Effects on DispositionProject

Lead & First Author | 2024–2025

Authors: Suzan Farhang-Sardroodi, Daniel Gonzalez, Cindy H. T. Yeung, Roberta M. Palmour, Sharon Miksys, and Rachel F. Tyndale.

Led the non-compartmental pharmacokinetic analysis using Phoenix WinNonlin and developed the population pharmacokinetic model using Phoenix NLME, integrating nonlinear mixed-effects modeling to characterize nicotine disposition across age and sex groups in African green monkeys. Identified body weight as the primary determinant of nicotine clearance and volume of distribution, establishing the first translational PopPK framework for nicotine disposition in this preclinical primate model.

Recorded Presentation: Available through CAMH Webex

Poster, Genome-Wide Multi-Trait Genomic and Transcriptomic Analyses of Smoking Behaviours and Schizophrenia Reveal New Biological Insights and Opportunities for Drug Repurposing, World Congress of Psychiatric Genetics (WCPG) 2025, October 19–23, 2025, Cancún, Mexico

Poster, Genome-Wide Multi-Trait Analysis of Smoking Behaviours and Schizophrenia Reveals New Biological Insights and Potential Opportunities for Drug Repurposing, Society of Biological Psychiatry's 2025 (SOBP 20025) Annual Meeting, Toronto, Canada, (April 24-26, 2025); also presented at Neuroscience and Clinical Translation Research Day, Department of Psychiatry, University of Toronto, Chelses hotel, Toronto, Canada (June 19, 2025)