In Preparation for Submission– Project 1

Title:
Genome-Wide Multi-Trait and Multimodal Single-Cell Analyses of Smoking Behaviours and Schizophrenia Reveal Novel Risk Loci

Authors: Suzan Farhang-Sardroodi¹, Jennie G. Pouget²˒³˒⁴, Saori Sakaue⁴˒⁵˒⁶˒⁷, Kathryn Weinand⁴, Soumya Raychaudhuri⁴˒⁵˒⁶, Jo Knight⁸, Rachel F. Tyndale¹˒²˒³, and Meghan J. Chenoweth¹˒²˒³

Affiliations:
¹ Department of Pharmacology & Toxicology, University of Toronto, Canada
² Department of Psychiatry, University of Toronto, Canada
³ Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada
⁴ Center for Data Sciences and Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, USA
⁵ Department of Biomedical Informatics, Harvard Medical School, USA
⁶ Program in Medical and Population Genetics, Broad Institute, USA
⁷ Department of Genome Sciences, University of Washington, USA
⁸ Data Science Institute and Lancaster University Medical School, Lancaster, UK

Project Duration:
January 8, 2024 – August 31, 2025 (for submission)

Summary:

This work integrates multi-trait genome-wide association studies and SCENT-based multimodal single-cell enhancer–gene mapping to identify novel loci and mechanisms linking tobacco smoking and schizophrenia, highlighting novel genes and potential drug targets. This work advances our understanding of the biology of tobacco smoking, a leading cause of preventable illness and death.