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Suzan Farhang-Sardroodi, M.Sc., Ph.D.
Web siteme hoş geldiniz
Temerty
Medicine
Current Projects
Completed Projects
Project 1
Genome-Wide Multi-Trait and Multimodal Single-Cell Analyses of Smoking Behaviours and Schizophrenia Reveal Novel Risk Loci and Regulatory Mechanisms
Authors: Suzan Farhang-Sardroodi, Jennie G. Pouget, Saori Sakaue, Kathryn Weinand, Soumya Raychaudhuri, Jo Knight, Rachel F. Tyndale, and Meghan J. Chenoweth
Institutions: University of Toronto, CAMH, Harvard Medical School, Broad Institute, University of Washington, Lancaster University
Project Period: 2024–2025
Summary: Integrated multi-trait GWAS (MTAG), eQTL colocalization, and multimodal single-cell enhancer–gene mapping (SCENT) analyses to identify novel loci and regulatory mechanisms linking smoking behaviours and schizophrenia. The study prioritized candidate genes including SYNDIG1L, TMEM163, CKB, and SLC8A2, and identified biologically relevant pathways and potential psychiatric drug targets associated with tobacco smoking behaviours.
Virtual Seminar, CAMH Addiction Research Rounds, Toronto, Canada, April 17, 2025 (12-1 pm online on Webex), (received a formal letter of thanks for this presentation)
Poster, Genome-Wide Multi-Trait Genomic and Transcriptomic Analyses of Smoking Behaviours and Schizophrenia Reveal New Biological Insights and Opportunities for Drug Repurposing, World Congress of Psychiatric Genetics (WCPG) 2025, October 19–23, 2025, Cancún, Mexico
Poster, Genome-Wide Multi-Trait Analysis of Smoking Behaviours and Schizophrenia Reveals New Biological Insights and Potential Opportunities for Drug Repurposing, Society of Biological Psychiatry's 2025 (SOBP 20025) Annual Meeting, Toronto, Canada, (April 24-26, 2025); also presented at Neuroscience and Clinical Translation Research Day, Department of Psychiatry, University of Toronto, Chelses hotel, Toronto, Canada (June 19, 2025)
Poster: Multi-Trait Genome-Wide Association Analysis of Psychiatric Traits Identified New Loci, American Society of Human Genetics (ASHG) Annual Meeting, Denver, Colorado, (Nov5-9, 2024). Online abstract: Board 5137T; Complex Traits and Polygenic Disorders.
Project 2
Population Pharmacokinetic Analysis of Nicotine in African Green Monkeys: Disentangling Sex, Age, and Body Weight Effects on Disposition
Authors: Suzan Farhang-Sardroodi, Daniel Gonzalez, Cindy H. T. Yeung, Roberta M. Palmour, Sharon Miksys, and Rachel F. Tyndale
Institutions: University of Toronto, Duke University, Dalhousie University, McGill University
Project Period: 2024–2026
Summary: Developed integrated non-compartmental and population pharmacokinetic (PopPK) models of nicotine disposition in African green monkeys using nonlinear mixed-effects modeling (Phoenix NLME). The project evaluated the effects of age, sex, and body weight on nicotine pharmacokinetics and identified body weight as a key determinant of nicotine clearance and distribution.
Recorded Presentation:
Webex Recording: https://camh.webex.com/recordingservice/sites/camh/recording/playback/5090e94a56314cdfb9e57761aad7ea74
Password: tMk7wWqC